About Mario
French
Native or bilingual
Spanish
Native or bilingual
English
Fluent
Experience
- Mario CANOPython, R and Linux-Ubuntu Courses for ScienceEDUCATION AND E-LEARNINGJanuary 2016 - Today (10 years and 5 months)Paris, France-I give Python and R courses in Windows and Linux-Ubuntu environments (all levels).-I specifically help with IT projects oriented towards Structural Bioinformatics, Biostatistics, as well as projects oriented towards the digital field: the use of these languages in Mathematics and Physics-Chemistry.
- MTi, Inserm UMR-S973, Université Paris Diderot (Maintenant Université Paris Cité)Project: Inhibition of HIV-2 protease: Study of resistance mechanisms by structural bioinformatics approaches and search for new specific inhibitors (HIV2-Bioinfo)RESEARCHMarch 2015 - December 2015 (10 months)Paris, FranceResearch Engineer.-Setup of datasets for structural comparison of HIV type 1 and type 2 proteases, as well as their inhibitors.-Comparison of the binding sites of inhibitors of HIV type 1 and type 2 proteases, using R and Python languages.-Development of QSAR (Quantitative structure-activity relationship) models to predict the activity of inhibitors against HIV type 1 and type 2 proteases. To develop these models, I was responsible for applying supervised machine learning methods, such as Linear Regression, Random Forest, and SVM (Support Vector Machine), always using Python and R languages in the Linux-Ubuntu environment.
- CNRS UMR 9187 – Inserm U1196 Institut Curie – Centre de rechercheProject: Microtubule movements during depolymerization studied by normal modes from atomic coordinates and electron microscopy imagesRESEARCHJanuary 2014 - June 2014 (6 months)Orsay, France-I was responsible for developing a new method, using the C programming language, to calculate the normal vibration modes (a property of biological systems) of a microtubule, from images obtained by electron microscopy, without using atomic coordinates.-Compare the results of the normal modes obtained by applying the method with theoretical values.-The goal of this project was to reduce the calculation time of normal modes obtained by considering atomic coordinates.
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